Owing to our long-winded experience in this domain, we are able to provide high grade Cyclophosamide Injection. Under the strict supervision of ingenious professionals, this injection is processed, tested and packed with maximum care by utilizing contemporary methodology. Acts as chemotherapy drug, it is injected in patients body for the treatment of cancer by disrupting cells growth. Also, this injection is highly effective against kidney disease in children. We put forward the offered Cyclophosamide Injection at cost effective prices.
Composition- : Each vial contains: Cyclophosphamide eq. to Cyclophosphamide (anhydrous) 200mg ,500mg,1000mg .
It is an antineoplastic and immuno modulating agent. It is bio-transformed in liver to active alkylated metabolite. These metabolites interfere with growth of susceptible rapidly multiplying malignant cells by cross-linking of tumour cell-DNA.
for injection, is a sterile white powder containing cyclophosphamide
monohydrate. Cyclophosphamide is a synthetic antineoplastic drug
chemically related to the nitrogen mustards. Cyclophosphamide is a white
crystalline powder with the molecular formula C7H15Cl2N2O2Pâ€˘H2O and a
molecular weight of 279.1. Cyclophosphamide is soluble in water,
saline, or ethanol .|
pH------------ 3.0 to 9.0
although effective alone in susceptible malignancies, is more
frequently used concurrently or sequentially with other antineoplastic
drugs. The following malignancies are often susceptible to
â€˘ Malignant lymphomas (Stages III and IV of the Ann Arbor staging system), Hodgkin's disease, lymphocytic lymphoma (nodular or diffuse), mixed-cell type lymphoma, histiocytic lymphoma, Burkitt's lymphoma.
â€˘ Multiple myeloma.
â€˘ Leukemias: Chronic lymphocytic leukemia, chronic granulocytic leukemia (it is usually ineffective in acute blastic crisis), acute myelogenous and monocyticleukemia, acute lymphoblastic (stem-cell) leukemia in children cyclophosphamide given during remission is effective in prolonging its duration)..
â€˘ Carcinoma of the breast.
|Dosage :-||Adults and Children:|
When used as the only oncolytic drug therapy, the initial course of cyclophosphamide for patients with no hematologic deficiency usually consists of 40 to 50 mg/kg given intravenously in divided doses over a period of 2 to 5 days. Other intravenous regimens include 10 to 15 mg/kg given every 7 to 10 days or 3 to 5 mg/kg twice weekly.
|Contraindications:-||In patients with history of hypersensitivity to the drug, pregnancy, location.|
attention to the possible development of toxicity should be exercised
in patients being treated with cyclophosphamide if any of the following
conditions are present.|
â€˘ Tumor cell infiltration of bone marrow
â€˘ Previous X-ray therapy
Previous therapy with other cytotoxic agents
physician should be alert for possible combined drug actions, desirable
or undesirable, involving cyclophosphamide even though cyclophosphamide
has been used successfully concurrently with other drugs, including
other cytotoxic drugs.Cyclophosphamide treatment, which causes a marked
and persistent inhibition of cholinesterase activity, potentiates the
effect of succinylcholine chloride.|
Since cyclophosphamide has been reported to be more toxic in adrenalectomized dogs, adjustment of the doses of both replacement steroids and cyclophosphamide may be necessary for the adrenalectomized patient.
|Adverse Effect-:||Sterility in both sexes may occur, amenorrhoea, haemorrhagic cystitis, fibrosis of bladder, nausea, vomitting, anorexia, alopecia, skin rash, pigmentation, leucopenia, thrombocytopenia, intestinal pulmonary fibrosis, anaphylactic reactions.|